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Research in Celiac Disease

In this section, the NFCA will post research related to celiac disease. In addition, articles of a less scientific nature, that will assist those with celiac in learning more about issues that affect their daily lives, will be posted.

Study Relates Celiac Disease & Migraine Headaches
A study published in the September issue of Cepalalgia finds that children with migraine headaches have an increased risk of developing celiac disease.
Last Updated 8/17/2008

Study Identifies Celiac Disease Receptor
New research may help patients get diagnosed with celiac disease sooner, cutting down on the average time of 10 years to get an accurate diagnosis. A study published in the July 2008 issue of the journal Gastroenterology finds and identifies a key gluten receptor in the small intestine that opens the gateway through which gluten enters the body and triggers the immune response in celiac patients.
Last Updated 8/17/2008

Digestive Disease Week Studies
Celiac experts filled room 32 of the San Diego Convention Center to talk about the latest advances in celiac disease. Dr. Bob Anderson from Australia explored basic scientific advances and had some very interesting things to point out.
Last Updated 7/12/2007

Economic Burden of a Gluten-Free Diet
This study found that gluten-free foods have poor availability and are more expensive than their gluten-containing counterparts. The researchers found that the availability of gluten-free products varied between grocery stores, upscale markets and health food stores.
Last Updated 7/12/2007

Non-Responsive Celiac Disease due to Inhaled Gluten
This study evaluated two patients who had nonresponsive celiac disease after having been on a gluten free diet. Both patients still showed chronic symptoms and histological changes from celiac but had adhered to a strictly gluten-free diet. Both patients worked on farms where they feed gluten-containing grain to livestock on a daily basis and were likely inhaling dust particles with gluten in them, thereby aggravating their symptoms even when no gluten was being ingested with their diets. Wearing face masks greatly improved symptoms and histological results for both patients.
Last Updated 7/10/2007

Genetic Risks for Celiac Disease
An international research study investigating the causes of intestinal inflammatory conditions has identified a new genetic risk factor for celiac disease. The study, lead by David van Heel a Professor at Queen Mary, University of London, found that celiacs often lack a protective DNA sequence in a specific gene region that is otherwise found in healthy individuals. This study has found that celiacs often lack a protective DNA sequence in the interleukin-2 and interleukin-21 gene region. Interleukin-2 and interleukin-21 are cytokine proteins secreted by white bloods cells that control inflammation, and both have been implicated in the mechanisms of other intestinal inflammatory diseases.
Last Updated 7/10/2007

Increased Risk of Death in Celiacs Diagnosed as Children
A study by at the University of Nottingham found that celiacs diagnosed as children have an increased occurrence of mortality due to violence, suicide, accidents, cancer and cerebrovascular disease. The study tracked 285 children and 340 adults who had been diagnosed with celiac disease in the Lothian region of Scotland.

Where Are All Those Patients With Celiac Disease?
Celiac disease is considered to occur in ∼1% of the U.S. population. It is, however, markedly underdiagnosed. In this issue, Fasano and his colleagues have continued their work in demonstrating just where all these patients are. Their current study explores a case finding policy in the primary practice setting. They identified patients who exhibited either symptoms that could be attributed to celiac disease, or had an associated condition. In this population, 2.25% had celiac disease. The study emphasizes the need for physician education in both the prevalence of celiac disease and the wide availability of the serological tests that can facilitate the diagnosis of celiac disease.

Detection of Celiac Disease in Primary Care: A Multicenter Case-Finding Study in North America
The aims of this study were (a) to determine whether an active case-finding strategy in primary care could increase the frequency of CD diagnosis and (b) to determine the most common clinical presentations of the condition.

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