Quantcast Study Shows Evidence of Non-Celiac Gluten Intolerance, But Cause Still Unclear | NFCA
Skip Navigation Links

Study Shows Evidence of Non-Celiac Gluten Intolerance, But Cause Still Unclear

Share |

 
2/18/2011

 

While many individuals report feeling better on a gluten-free diet even when celiac disease has been ruled out, there has been little research into gluten as a trigger for non-celiac digestive issues, according to researchers in Australia. The group set out to change that, publishing a study in the American Journal of Gastroenterology on Jan. 11, 2011, that documented evidence of “non-celiac gluten intolerance.”

The study examined 34 patients with irritable bowel syndrome who followed a gluten-free diet. Of the participants, 56% had human leukocyte antigen (HLA)-DQ2 and/or HLA-DQ8, but celiac disease was ruled out in all cases. Participants were given either gluten or a placebo in the form of two slices of bread and a muffin each day for up to 6 weeks. Remaining food intake followed the gluten-free diet.

Of the 19 patients given gluten, 13 reported that symptoms were “not adequately controlled” after the gluten challenge, according to the study. Of the 15 who took a placebo, only 6 reported such a change in symptoms.  Participants who ingested gluten showed a worsening in overall symptoms, pain, bloating, satisfaction with stool consistency, and tiredness, according to the study. However, there were no changes in antibody levels or intestinal permeability, regardless of whether the participant had DQ2/DQ8 or not, the researchers noted.

“’Non-celiac gluten intolerance’ may exist, but no clues to the mechanism were elucidated,” they concluded.

 

 

Note: NFCA maintains the position that views and information presented on articles and websites we link to are those of the authors, and not necessarily those of NFCA.
 

<< Back to Research News


 

 
 
  • Have you or your family members been diagnosed?
    Complete our celiac disease symptoms checklist today to find out if you are at risk of having celiac disease / gluten intolerance. We can help improve the quality of your life!
  • Stay Informed!
    Join our monthly newsletter to receive news, updates, and tips for healthy gluten-free living and information about celiac disease. Sign-up for the monthly e-mail newsletter